ARG45181
anti-TAB2 antibody
anti-TAB2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TAB2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TAB2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human TAB2. |
| Conjugation | Un-conjugated |
| Alternate Names | TAB2; TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein; MAP3K7IP2; KIAA0733; Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2; TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2; TAK1-Binding Protein 2; TAB-2; Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2; TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein; TGF-Beta-Activated Kinase 1-Binding Protein 2; TAK1 Binding Protein 2; CHTD2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 76 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NYJ8 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
|---|---|
| Gene Symbol | TAB2 |
| Gene Full Name | TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2 |
| Background | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). [UniProt] |
| Cellular Localization | Membrane; Endosome membrane; Lysosome membrane; Cytoplasm, cytosol. [UniProt] |
| Calculated MW | 76 kDa |
| PTM | Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG45181 anti-TAB2 antibody IHC-P image
Immunohistochemistry: Human rectal cancer stained with ARG45181 anti-TAB2 antibody at 2 μg/ml dilution.
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ARG45181 anti-TAB2 antibody WB image
Western blot: Hela, A549, and HepG2 stained with ARG45181 anti-TAB2 antibody at 0.5 μg/ml dilution.
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ARG45181 anti-TAB2 antibody FACS image
Flow Cytometry: U87 stained with ARG45181 anti-TAB2 antibody at 1 µg/10^6 cells dilution.
