ARG54684
anti-TAB1 antibody
anti-TAB1 antibody for ELISA,ICC/IF,Western blot and Human,Mouse
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TAB1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ELISA, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TAB1 |
| Immunogen | Synthetic peptide (13 aa) within aa. 220-270 of Human TAB1. |
| Conjugation | Un-conjugated |
| Alternate Names | MAP3K7IP1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; 3'-Tab1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | 3T3 Cell Lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q15750 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Swiss-port # Q8CF89 Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
|---|---|
| Gene Symbol | TAB1 |
| Gene Full Name | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Background | TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1. |
| Function | May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody |
| Calculated MW | 55 kDa |
| PTM | Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP. |
Images (3) Click the Picture to Zoom In
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ARG54684 anti-TAB1 antibody ICC/IF image
Immunocytochemistry: K562 cells stained with ARG54684 anti-TAB1 antibody at 1 μg/ml.
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ARG54684 anti-TAB1 antibody ICC/IF image
Immunofluorescence: 3T3 cells stained with ARG54684 anti-TAB1 antibody at 2 μg/ml.
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ARG54684 anti-TAB1 antibody WB image
Western blot: 3T3 cell lysate stained with ARG54684 anti-TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 μg/ml.
Customer's Feedback
Average
Review for anti-TAB1 antibody
Application：WB
Sample：HeLa
Sample Loading Amount：30 µg
Primary Antibody Dilution Factor：1:500
Primary Antibody Incubation Time：overnight
Primary Antibody Incubation Temperature：4 ºC
