ARG67047
anti-Survivin antibody [SQab30320]
anti-Survivin antibody [SQab30320] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant rabbit Monoclonal antibody [SQab30320] recognizes Survivin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30320 |
| Isotype | IgG |
| Target Name | Survivin |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human Survivin. |
| Conjugation | Un-conjugated |
| Protein Full Name | Baculoviral IAP repeat-containing protein 5 |
| Alternate Names | BIRC5, Baculoviral IAP Repeat Containing 5, Apoptosis Inhibitor 4, EPR-1, API4, Baculoviral IAP Repeat-Containing Protein 5, Apoptosis Inhibitor Survivin, Survivin, Baculoviral IAP Repeat-Containing 5, IAP4 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Human tonsil |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05%BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O15392 Human Baculoviral IAP repeat-containing protein 5 |
|---|---|
| Gene Symbol | BIRC5 |
| Gene Full Name | Baculoviral IAP Repeat Containing 5 |
| Background | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| Function | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesi. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. [Uniprot] |
| Cellular Localization | Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus |
| Calculated MW | 16 kDa |
| PTM | Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67047 anti-Survivin antibody [SQab30320] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded human tonsil stained with ARG67047 anti-Survivin antibody [SQab30320].
