ARG56550
anti-Substance P antibody [NC1/34]
anti-Substance P antibody [NC1/34] for ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat,Rabbit
Overview
| Product Description | Rat Monoclonal antibody [NC1/34] recognizes Substance P |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Rb |
| Predict Reactivity | Cyfsh, Mamm, Pgn |
| Tested Application | ICC/IF, IHC-Fr, IHC-P |
| Specificity | This antibody recognizes the COOH-terminal end of substance P. It does not recognize Leu- or Met enkephalin, somatostatin or beta-endorphin; Cross-reactivity with eledoisin: 5%. It recognizes Substance P in postmortem tissue of the human brain. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | NC1/34 |
| Isotype | IgG2a |
| Target Name | Substance P |
| Antigen Species | Human |
| Immunogen | Substance P |
| Conjugation | Un-conjugated |
| Alternate Names | NKA; NKNA; NPK; TAC2; Neuromedin L; NK2; PPT; Protachykinin-1; Substance K; Hs.2563 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|---|---|
| Application Note | Rabbit samples have been tested on O.C.T. embedded formaldehyde fixed frozen tissue sections only. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Non Purified. |
| Buffer | Tissue culture supernatant and 0.05% Thimerosal. |
| Preservative | 0.05% Thimerosal |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TAC1 |
| Gene Full Name | tachykinin, precursor 1 |
| Background | This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. [UniProt] |
| Calculated MW | 15 kDa |
| PTM | The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). |
