ARG58448
anti-Sp7 / Osterix antibody
anti-Sp7 / Osterix antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes Sp7 / Osterix |
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Tested Reactivity | Hu |
Predict Reactivity | Ms, Rat, Cow, Gpig, Hrs, Rb |
Tested Application | IHC-P |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | Sp7 / Osterix |
Antigen Species | Human |
Immunogen | Synthetic peptide around the C-terminal region of Human Sp7 / Osterix. (within the following sequence: RTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPGGSP) |
Conjugation | Un-conjugated |
Alternate Names | Transcription factor Sp7; OI11; osterix; OSX; OI12; Zinc finger protein osterix |
Application Instructions
Predict Reactivity Note | Predicted homology based on immunogen sequence: Cow: 100%; Guinea Pig: 93%; Horse: 93%; Mouse: 92%; Rabbit: 86%; Rat: 93% | ||||
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Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | Jurkat |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
Preservative | 0.09% (w/v) Sodium azide |
Stabilizer | 2% Sucrose |
Concentration | Batch dependent: 0.5 - 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | SP7 |
Gene Full Name | Sp7 transcription factor |
Background | This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] |
Function | Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). [UniProt] |
Calculated MW | 45 kDa |
PTM | Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. [UniProt] |
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