ARG56008
anti-Semaphorin 4D antibody [A8]
anti-Semaphorin 4D antibody [A8] for Flow cytometry,ICC/IF and Human,Mouse
Overview
| Product Description | Mouse Monoclonal antibody [A8] recognizes Semaphorin 4D |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | FACS, ICC/IF |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | A8 |
| Isotype | IgG1, kappa |
| Target Name | Semaphorin 4D |
| Antigen Species | Human |
| Immunogen | PHA stimulated Human peripheral blood lymphocytes. |
| Conjugation | Un-conjugated |
| Alternate Names | CD100; GR3; CD antigen CD100; M-sema-G; BB18; C9orf164; SEMAJ; Semaphorin-4D; A8; coll-4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SEMA4D |
| Gene Full Name | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
| Function | Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. [UniProt] |
| Cellular Localization | Cell surface |
| Calculated MW | 96 kDa |
