ARG45104
anti-STRADB/PAPK antibody
anti-STRADB/PAPK antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes STRADB/PAPK. |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | STRADB |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide corresponding to amino acids from the C-terminal region of mouse STRADB/PAPK protein. |
| Conjugation | Un-conjugated |
| Alternate Names | STRADB; STE20 Related Adaptor Beta; CALS-21; ILPIP; ALS2CR2; ILPIPA; PAPK; Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 2; STE20-Related Kinase Adapter Protein Beta; STE20-Related Kinase Adaptor Beta; seudokinase ALS2CR2; STRAD Beta; ILP-Interacting Protein ILPIPA; ILP-Interacting Protein; PRO1038 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.02% NaN3 |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8K4T3 Mouse STE20-related kinase adapter protein beta |
|---|---|
| Gene Symbol | Stradb |
| Gene Full Name | STE20 Related Adaptor Beta |
| Background | This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this ge |
| Function | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. [Uniprot] |
| Cellular Localization | Cytoplasm, Nucleus. [Uniprot] |
| Calculated MW | 48 kDa |
