ARG66890
anti-SLC26A3 / DRA antibody
anti-SLC26A3 / DRA antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SLC26A3 / DRA |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SLC26A3 / DRA |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from the C-terminal region of Human SLC26A3 / DRA. |
| Conjugation | Un-conjugated |
| Alternate Names | CLD; Chloride anion exchanger; Down-regulated in adenoma; DRA; Protein DRA; Solute carrier family 26 member 3 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | 293 and HeLa | ||||
| Observed Size | ~ 85 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SLC26A3 |
| Gene Full Name | solute carrier family 26 (anion exchanger), member 3 |
| Background | The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] |
| Function | Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. [UniProt] |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). [UniProt] |
| Calculated MW | 85 kDa |
| PTM | N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG66890 anti-SLC26A3 / DRA antibody WB image
Western blot: 293 and HeLa cell lysates stained with ARG66890 anti-SLC26A3 / DRA antibody.
