ARG45376
anti-SIGIRR antibody [10D5]
anti-SIGIRR antibody [10D5] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [10D5] recognizes SIGIRR |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 10D5 |
| Isotype | IgG2 |
| Target Name | SIGIRR |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to extracellular domain of human SIGIRR. |
| Conjugation | Un-conjugated |
| Alternate Names | SIGIRR; Single Ig And TIR Domain Containing; TIR8; Toll/Interleukin-1 Receptor 8; IL-1R8; Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain; Single Immunoglobulin Domain-Containing IL1R-Related Protein; Single Immunoglobulin Domain IL1R1 Related; Single Ig IL-1R-Related Molecule; Single Ig IL-1-Related Receptor |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G chromatography |
| Buffer | PBS |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SIGIRR |
| Gene Full Name | Single Ig And TIR Domain Containing |
| Background | Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024] |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Cellular Localization | Membrane. [UniProt] |
| Calculated MW | 46 kDa |
| PTM | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
Images (1) Click the Picture to Zoom In
-
ARG45376 anti-SIGIRR antibody [10D5] IHC-P image
Immunohistochemistry: Human placenta stained with ARG45376 anti-SIGIRR antibody [10D5].
