ARG44318
anti-SHPRH antibody
anti-SHPRH antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SHPRH |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SHPRH |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | SHPRH; SNF2 Histone Linker PHD RING Helicase; BA545I5.2; KIAA2023; SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase; SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase SHPRH; E3 Ubiquitin-Protein Ligase SHPRH; FLJ90837 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SHPRH |
| Gene Full Name | SNF2 Histone Linker PHD RING Helicase |
| Background | SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5. |
| Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. |
| Calculated MW | 193 kDa |
| PTM | Phosphoprotein |
