ARG59505
anti-SFTPC / SP-C antibody
anti-SFTPC / SP-C antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SFTPC / SP-C |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SFTPC / SP-C |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-197 of Human SFTPC / SP-C (NP_001165881.1). |
| Conjugation | Un-conjugated |
| Alternate Names | BRICD6; SP-C; Val; SFTP2; SP5; PSP-C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL; SMDP2 |
Application Instructions
| Predict Reactivity Note | Rat | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Mouse pancreas and K562 | ||||||||
| Observed Size | 21 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P11685 Rat Pulmonary surfactant-associated protein C Swiss-port # P11686 Human Pulmonary surfactant-associated protein C |
|---|---|
| Gene Symbol | SFTPC |
| Gene Full Name | surfactant protein C |
| Background | This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010] |
| Function | Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. [UniProt] |
| Cellular Localization | Secreted, extracellular space, surface film. [UniProt] |
| Calculated MW | 21 kDa |
Images (3) Click the Picture to Zoom In
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ARG59505 anti-SFTPC / SP-C antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung stained with ARG59505 anti-SFTPC / SP-C antibody at 1:100 dilution.
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ARG59505 anti-SFTPC / SP-C antibody WB image
Western blot: 25 µg of Mouse pancreas and K562 cell lysate stained with ARG59505 anti-SFTPC / SP-C antibody at 1:1000 dilution.
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ARG59505 anti-SFTPC / SP-C antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer stained with ARG59505 anti-SFTPC / SP-C antibody at 1:100 dilution.
