ARG59868
anti-SFRS9 antibody
anti-SFRS9 antibody for ICC/IF,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SFRS9 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SFRS9 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-221 of Human SFRS9 (NP_003760.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Serine/arginine-rich splicing factor 9; Pre-mRNA-splicing factor SRp30C; Splicing factor, arginine/serine-rich 9; SRp30c; SFRS9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse testis and BT-474 | ||||||
| Observed Size | 24 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13242 Human Serine/arginine-rich splicing factor 9 Swiss-port # Q9D0B0 Mouse Serine/arginine-rich splicing factor 9 |
|---|---|
| Gene Symbol | SRSF9 |
| Gene Full Name | serine/arginine-rich splicing factor 9 |
| Background | The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010] |
| Function | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. [UniProt] |
| Cellular Localization | Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells. [UniProt] |
| Calculated MW | 26 kDa |
| PTM | Extensively phosphorylated on serine residues in the RS domain. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG59868 anti-SFRS9 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG59868 anti-SFRS9 antibody at 1:100 dilution.
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ARG59868 anti-SFRS9 antibody WB image
Western blot: 25 µg of Mouse testis and BT-474 cell lysates stained with ARG59868 anti-SFRS9 antibody at 1:1000 dilution.
