ARG63243
anti-SETMAR antibody
anti-SETMAR antibody for Western blot and Human
Gene Regulation antibody
Overview
Product Description | Goat Polyclonal antibody recognizes SETMAR |
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Tested Reactivity | Hu |
Predict Reactivity | Cow |
Tested Application | WB |
Host | Goat |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | SETMAR |
Antigen Species | Human |
Immunogen | RWQKCVDCNGSYFD |
Conjugation | Un-conjugated |
Alternate Names | HsMar1; SET domain and mariner transposase fusion protein; EC 3.1.-.-; EC 2.1.1.43; Mar1; METNASE; Histone-lysine N-methyltransferase SETMAR; Metnase |
Application Instructions
Application Suggestion |
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Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
Preservative | 0.02% Sodium azide |
Stabilizer | 0.5% BSA |
Concentration | 0.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q53H47 Human Histone-lysine N-methyltransferase SETMAR |
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Background | This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
Research Area | Gene Regulation antibody |
Calculated MW | 78 kDa |
PTM | Methylated. Methylation regulates activity in DNA decatenation. Phosphorylated at Ser-508 by CHEK1 and dephosphorylated by protein phosphatase 2A/PP2A. Phosphorylation at Ser-508 is enhanced by DNA damage and promotes recruitment to damaged DNA. It stimulates DNA repair and impairs replication fork restart. |
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