ARG58286

anti-SERPING1 / C1 Inhibitor antibody

anti-SERPING1 / C1 Inhibitor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes SERPING1 / C1 Inhibitor
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name SERPING1 / C1 Inhibitor
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 351-379 of Human SERPING1 / C1 Inhibitor.
Conjugation Un-conjugated
Alternate Names C1IN; C1INH; C1-inhibiting factor; Serpin G1; C1 esterase inhibitor; Plasma protease C1 inhibitor; C1 Inh; HAE2; C1Inh; C1NH; HAE1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:100
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human blood plasma

Properties

Form Liquid
Purification Purified
Buffer PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 710 Human SERPING1

Swiss-port # P05155 Human Plasma protease C1 inhibitor

Gene Symbol SERPING1
Gene Full Name serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Background This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
Function Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. [UniProt]
Calculated MW 55 kDa
PTM Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

Can be proteolytically cleaved by E.coli stcE. [UniProt]

Images (2) Click the Picture to Zoom In

  • ARG58286 anti-SERPING1 / C1 Inhibitor antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG58286 anti-SERPING1 / C1 Inhibitor antibody.

  • ARG58286 anti-SERPING1 / C1 Inhibitor antibody WB image

    Western blot: 35 µg of Human blood plasma lysate stained with ARG58286 anti-SERPING1 / C1 Inhibitor antibody at 1:1000 dilution.