ARG64911
anti-SCARB2 / LIMP2 antibody
anti-SCARB2 / LIMP2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes SCARB2 / LIMP2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SCARB2 / LIMP2 |
| Antigen Species | Human |
| Immunogen | C-NKANIQFGDNGTTIS |
| Conjugation | Un-conjugated |
| Protein Full Name | Lysosome membrane protein 2 |
| Alternate Names | EPM4; LIMP-2; CD36L2; LIMPII; CD antigen CD36; LGP85; AMRF; LIMP II; HLGP85; Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; Lysosome membrane protein II; CD36 antigen-like 2; Scavenger receptor class B member 2; SR-BII |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Human cerebral cortex | ||||||
| Observed Size | ~ 80 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SCARB2 |
| Gene Full Name | scavenger receptor class B member 2 |
| Background | The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] |
| Research Area | Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 54 kDa |
Images (2) Click the Picture to Zoom In
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ARG64911 anti-SCARB2 / LIMP2 antibody IHC image
Immunohistochemistry: Paraffin-embedded Human cerebral cortex tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64911 anti-SCARB2 / LIMP2 antibody at 3.8 µg/ml dilution, followed by AP-staining.
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ARG64911 anti-SCARB2 / LIMP2 antibody WB image
Western blot: 35 µg of Human cerebral cortex lysate stained with ARG64911 anti-SCARB2 / LIMP2 antibody at 0.1 µg/ml dilution and incubated at RT for 1 hour.
