ARG44926

anti-SAP18 antibody

Ordering Information

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Price (USD)

50 μg

325.00

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Datasheet

Overview

Product Description	Mouse Monoclonal antibody recognizes SAP18
Tested Reactivity	Hu
Tested Application	IHC-P
Host	Mouse
Clonality	Monoclonal
Isotype	IgG2a
Target Name	SAP18
Antigen Species	Human
Epitope	EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP
Conjugation	Un-conjugated
Alternate Names	SAP18; Sin3A Associated Protein 18; 2HOR0202; SAP18p; Histone Deacetylase Complex Subunit SAP18; Cell Growth-Inhibiting Gene 38 Protein; 18 KDa Sin3-Associated Polypeptide; Sin3A-Associated Protein, 18kDa; MGC27131; Epididymis Secretory Sperm Binding Protein; Histone Deacetlyase Complex Subunit SAP18; Sin3-Associated Polypeptide, 18 KDa; Cell Growth Inhibiting Protein 38; Sin3-Associated Polypeptide, P18; Sin3-Associated Polypeptide P18

Application Instructions

Application Suggestion

Tested Application	Dilution
IHC-P	1:100~1:200

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Protein A purification
Buffer	PBS with 0.09% sodium azide
Preservative	0.09% sodium azide
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol	SAP18
Gene Full Name	Sin3A Associated Protein 18
Background	Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Function	Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. [UniProt]
Cellular Localization	Cytoplasm, Nucleus. [UniProt]
Calculated MW	18 kDa
PTM	Acetylation, Isopeptide bond, Ubl conjugation. [UniProt]