ARG10589
anti-S100 antibody [D28-E]
anti-S100 antibody [D28-E] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [D28-E] recognizes S100 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | D28-E |
| Isotype | IgG |
| Target Name | S100 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the C-terminus of Human S100-A1 protein |
| Conjugation | Un-conjugated |
| Alternate Names | S-100 protein subunit alpha; S100 calcium-binding protein A1; S-100 protein alpha chain; S100-alpha; S100; Protein S100-A1; S100A |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 20 mg/ml BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | S100A1 |
| Gene Full Name | S100 calcium binding protein A1 |
| Background | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008] |
| Function | Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. [UniProt] |
| Calculated MW | 11 kDa |
Images (1) Click the Picture to Zoom In
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ARG10589 anti-S100 antibody [D28-E] IHC-P image
Immunohistochemistry: Formalin fixed, paraffin embedded Human cutaneous malignant melanoma (4 µm section) stained with ARG10589 anti-S100 antibody [D28-E].
