ARG44018
anti-RTN4 / Nogo A antibody
anti-RTN4 / Nogo A antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RTN4 / Nogo A |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RTN4 / Nogo A |
| Antigen Species | Human |
| Immunogen | Human RTN4 / Nogo A recombinantprotein |
| Conjugation | Un-conjugated |
| Protein Full Name | Reticulon-4 |
| Alternate Names | RTN4; Reticulon 4; NOGO; KIAA0886; NSP-CL; ASY; Neuroendocrine-Specific Protein C Homolog; Neurite Outgrowth Inhibitor; Reticulon-4; Foocen; RTN-X; NSP; Neuroendocrine-Specific Protein; Neurite Growth Inhibitor 220; My043 Protein; Nogo Protein; Human NogoA; Reticulon 5; Reticulon-5; NI220/250; Nbla00271; Nbla10545; RTN4-B1; RTN4-B2; RTN4-A; RTN4-C |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS containing 0.02% sodium azide |
| Preservative | 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RTN4 |
| Gene Full Name | Reticulon 4 |
| Background | This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. |
| Function | Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. |
| Cellular Localization | Cell junction, Cell membrane, Endoplasmic reticulum, Membrane |
| Calculated MW | 130 kDa |
| PTM | Acetylation, Phosphoprotein |
Images (2) Click the Picture to Zoom In
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ARG44018 anti-RTN4 / Nogo A antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG44018 anti-RTN4 / Nogo A antibody at 20 μg/mL dilution.
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ARG44018 anti-RTN4 / Nogo A antibody WB image
Western blot: Human brain stained with ARG44018 anti-RTN4 / Nogo A antibody at 1 μg/mL dilution.
