ARG65743
anti-ROR1 antibody
anti-ROR1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Goat Polyclonal antibody recognizes ROR1 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat |
| Tested Application | IHC-P |
| Specificity | This antibody is expected to recognize isoform 1 (NP_005003.2) only. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ROR1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the C-terminus of Human ROR1. (C-GNKSQKPYKIDSKQA) |
| Conjugation | Un-conjugated |
| Alternate Names | Tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; EC 2.7.10.1; NTRKR1; dJ537F10.1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q01973 Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
|---|---|
| Gene Symbol | ROR1 |
| Gene Full Name | receptor tyrosine kinase-like orphan receptor 1 |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| Function | Tyrosine-protein kinase receptor whose role is not yet clear. [UniProt] |
| Calculated MW | 104 kDa |
Images (3) Click the Picture to Zoom In
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ARG65743 anti-ROR1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human prostate tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG65743 anti-ROR1 antibody at 3 µg/ml dilution followed by AP-staining.
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ARG65743 anti-ROR1 antibody IHC-P image
Immunohistochemistry: paraffin-embedded Human breast cancer tissue stained with ARG65743 anti-ROR1 antibody at 5 µg/ml dilution. Heated antigen retrieval with citrate buffer pH 6, DAB-staining.
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ARG65743 anti-ROR1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG65743 anti-ROR1 antibody at 3 µg/ml dilution followed by AP-staining.
