ARG57719

anti-RNASEN / Drosha antibody

Datasheet

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100 μl

389.00

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Overview

Product Description	Rabbit Polyclonal antibody recognizes RNASEN / Drosha
Tested Reactivity	Hu
Tested Application	FACS, ICC/IF, IHC-P, WB
Specificity	This antibody detects endogenous levels of total Drosha.
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	RNASEN / Drosha
Antigen Species	Human
Immunogen	Synthetic peptide from Human RNASEN / Drosha.
Conjugation	Un-conjugated
Alternate Names	p241; RNASE3L; ETOHI2; RNase III; EC 3.1.26.3; Ribonuclease III; Protein Drosha; Ribonuclease 3; RANSE3L; HSA242976; RN3; RNASEN

Application Instructions

Application Suggestion

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 29102 Human DROSHA Swiss-port # Q9NRR4 Human Ribonuclease 3
Gene Symbol	DROSHA
Gene Full Name	drosha, ribonuclease type III
Background	Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]
Function	Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. [UniProt]
Calculated MW	159 kDa