Overview

Product Description	Rabbit Polyclonal antibody recognizes RFXANK
Tested Reactivity	Hu
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	RFXANK
Antigen Species	Human
Immunogen	Synthetic peptide
Conjugation	Un-conjugated
Alternate Names	RFXANK; Regulatory Factor X Associated Ankyrin Containing Protein; ANKRA1; RFX-B; Regulatory Factor X Subunit B; DNA-Binding Protein RFXANK

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:500-1:1000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Antigen Affinity Purified
Buffer	PBS with 0.02% Sodium azide
Preservative	0.02% Sodium azide
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Bioinformation

Database Links	GeneID: 8625 Human RFXANK Swiss-port # O14593 Human DNA-binding protein RFXANK
Gene Symbol	RFXANK
Gene Full Name	Regulatory Factor X Associated Ankyrin Containing Protein
Background	Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Function	Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters.
Cellular Localization	Cytoplasm, Nucleus
Calculated MW	28 kDa

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