ARG44907
anti-RAPGEF4 / EPAC2 antibody
anti-RAPGEF4 / EPAC2 antibody for IHC-Formalin-fixed paraffin-embedded sections and Mouse
Overview
| Product Description | Mouse Monoclonal antibody recognizes RAPGEF4 / EPAC2 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | RAPGEF4 / EPAC2 |
| Antigen Species | Mouse |
| Epitope | EDFNRILRDV EANTVRLKEH |
| Conjugation | Un-conjugated |
| Alternate Names | RAPGEF4; Rap Guanine Nucleotide Exchange Factor 4; CAMP-GEFII; CGEF2; CAMP-Regulated Guanine Nucleotide Exchange Factor II; Exchange Protein Directly Activated By CAMP 2; RAP Guanine-Nucleotide-Exchange Factor (GEF) 4; Rap Guanine Nucleotide Exchange Factor (GEF) 4; Exchange Factor Directly Activated By CAMP 2; EPAC 2; EPAC2; Putative Protein Product Of Nbla00496; Nbla00496; EPAC |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9EQZ6 Mouse Rap guanine nucleotide exchange factor 4 |
|---|---|
| Gene Symbol | RAPGEF4 |
| Gene Full Name | Rap Guanine Nucleotide Exchange Factor 4 |
| Background | Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Apr 2022] |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. [Uniprot] |
| Cellular Localization | Cytoplasm, Membrane. [Uniprot] |
| Calculated MW | 116 kDa |
Images (1) Click the Picture to Zoom In
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ARG44907 anti-RAPGEF4 / EPAC2 antibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG44907 anti-RAPGEF4 / EPAC2 antibody at 4.23 µg/mL dilution.
