ARG64669
anti-RAB17 antibody
anti-RAB17 antibody for Western blot and Mouse
Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes RAB17 |
|---|---|
| Tested Reactivity | Ms |
| Predict Reactivity | Rat |
| Tested Application | WB |
| Specificity | Reported variants represent identical protein (NP_001153197.2; NP_033024.1). |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RAB17 |
| Antigen Species | Mouse |
| Immunogen | C-RKDSFHKAQQWLED |
| Conjugation | Un-conjugated |
| Alternate Names | Ras-related protein Rab-17 |
Application Instructions
| Application Suggestion |
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| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Rab17 |
| Gene Full Name | RAB17, member RAS oncogene family |
| Background | The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009] |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration. [UniProt] |
| Research Area | Signaling Transduction antibody |
| Calculated MW | 23 kDa |
Images (1) Click the Picture to Zoom In
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ARG64669 anti-RAB17 antibody WB image
Western blot: Mouse Kidney lysate (35 µg protein in RIPA buffer) stained with ARG64669 anti-RAB17 antibody at 0.2 µg/ml dilution.
