ARG64643

anti-Proenkephalin antibody

anti-Proenkephalin antibody for IHC-Frozen sections and Mouse,Rat

Neuroscience antibody

Overview

Product Description Goat Polyclonal antibody recognizes Proenkephalin
Tested Reactivity Ms, Rat
Tested Application IHC-Fr
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name Proenkephalin
Antigen Species Mouse
Immunogen C-YKDSSKQDESH
Conjugation Un-conjugated
Alternate Names 143-183; PENK-A; PE; 114-133; Proenkephalin-A; 237-258; OGF; Opioid growth factor

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-Fr0.02 - 0.05 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 18619 Mouse PENK

GeneID: 29237 Rat PENK

Swiss-port # P04094 Rat Proenkephalin-A

Swiss-port # P22005 Mouse Proenkephalin-A

Gene Symbol Penk
Gene Full Name preproenkephalin
Background This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Function Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. [UniProt]
Research Area Neuroscience antibody
Calculated MW 31 kDa
PTM The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Images (2) Click the Picture to Zoom In

  • ARG64643 anti-Proenkephalin antibody IHC-Fr image

    Immunohistochemistry: PFA-perfused cryosection of Rat striatum tissue stained with ARG64643 anti-Proenkephalin antibody at 0.02 µg/ml dilution.

  • ARG64643 anti-Proenkephalin antibody IHC-Fr image

    Immunohistochemistry: PFA-perfused cryosection of Mouse stria terminalis tissue stained with ARG64643 anti-Proenkephalin antibody at 0.02 µg/ml dilution.