ARG62588
anti-PTHR1 antibody [3D1.1]
anti-PTHR1 antibody [3D1.1] for Immunohistochemistry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [3D1.1] recognizes PTHR1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 3D1.1 |
| Isotype | IgG1, kappa |
| Target Name | PTHR1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to amino acids 146-169 of the human PTH/PTHrP receptor (RRCDRNGSWELVPGHNRTWANYSE). |
| Conjugation | Un-conjugated |
| Alternate Names | Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; Parathyroid hormone 1 receptor; PTHR1; PTH/PTHr receptor; PFE; PTHR; PTH1 receptor |
Application Instructions
| Application Note | WB: 0.5-2 ug/ml IHC: 1/10 - 1/500 IHC-P: 5 ug/ml * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G purified |
| Buffer | 1X PBS buffer with <0.1% sodium azide. |
| Preservative | <0.1% sodium azide. |
| Concentration | 2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q03431 Human Parathyroid hormone/parathyroid hormone-related peptide receptor |
|---|---|
| Gene Symbol | PTH1R |
| Gene Full Name | parathyroid hormone 1 receptor |
| Background | The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] |
| Function | This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. [UniProt] |
| Research Area | Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 66 kDa |
Clone References
The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit.
IHC-P / Rabbit
Expression of parathyroid-hormone- related protein in the partially obstructed rabbit bladder.
IHC-P / Rabbit
Expression and specific immunolocalization of the human parathyroid hormone/parathyroid hormone-related protein receptor in the uteroplacental unit.
