ARG43997
anti-PSMD2 / Proteasome 26S S2 antibody
anti-PSMD2 / Proteasome 26S S2 antibody for ELISA,ICC/IF,Western blot and Human,Rat,Monkey
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PSMD2 / Proteasome 26S S2 |
|---|---|
| Tested Reactivity | Hu, Rat, Mk |
| Tested Application | ELISA, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PSMD2 / Proteasome 26S S2 |
| Antigen Species | Human |
| Immunogen | Human PSMD2 / Proteasome 26S S2 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | 26S proteasome non-ATPase regulatory subunit 2 |
| Alternate Names | PSMD2; Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2; TRAP2; P97; S2; Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2; Tumor Necrosis Factor Type 1 Receptor-Associated Protein 2; 26S Proteasome Non-ATPase Regulatory Subunit 2; Proteasome 26S Subunit, Non-ATPase 2; Protein 55.11; MGC14274; Rpn1; 26S Proteasome Regulatory Subunit RPN1; 26S Proteasome Regulatory Subunit S2; 26S Proteasome Subunit P97; TNFR-Associated Protein 2; 55.11 Protein; RPN1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # Q13200 Human 26S proteasome non-ATPase regulatory subunit 2 Swiss-port # Q4FZT9 Rat 26S proteasome non-ATPase regulatory subunit 2 |
|---|---|
| Gene Symbol | PSMD2 |
| Gene Full Name | Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2 |
| Background | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. |
| Cellular Localization | Proteasome |
| Calculated MW | 100 kDa |
| PTM | Acetylation, Phosphoprotein |
Images (4) Click the Picture to Zoom In
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ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody ICC/IF image
Immunofluorescence: U20S cells stained withARG43997 anti-PSMD2 / Proteasome 26S S2 antibody at 5 μg/ml dilution.
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ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody WB image
Western blot: PC-3 stained with ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody at 0.25 μg/mL dilution.
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ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody WB image
Western blot: Rat heart stained with ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody at 0.25 μg/mL dilution.
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ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody WB image
Western blot: COS-7 stained with ARG43997 anti-PSMD2 / Proteasome 26S S2 antibody at 0.25 μg/mL dilution.
