ARG44069
anti-PRMT7 antibody
anti-PRMT7 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Gene Regulation antibody
Overview
| Product Description | Rabbit Polyclonal recognizes PRMT7 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PRMT7 |
| Antigen Species | Human |
| Immunogen | Human PRMT7 recombinant protein (Position: K121-D526). |
| Conjugation | Un-conjugated |
| Alternate Names | PRMT7; Protein Arginine Methyltransferase 7; KIAA1933; [Myelin Basic Protein]-Arginine N-Methyltransferase PRMT7; Histone-Arginine N-Methyltransferase PRMT7; Protein Arginine N-Methyltransferase 7; FLJ10640; EC 2.1.1.321; EC 2.1.1; SBIDDS |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PRMT7 |
| Gene Full Name | Protein Arginine Methyltransferase 7 |
| Background | Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008] |
| Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. |
| Cellular Localization | Cytoplasm, Nucleus |
| Research Area | Gene Regulation antibody |
| Calculated MW | 78 kDa |
| PTM | Methylation |
Images (5) Click the Picture to Zoom In
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ARG44069 anti-PRMT7 antibody IHC-P image
Immunohistochemistry: Human ovarian cancer stained with ARG44069 anti-PRMT7 antibody at 2 μg/mL dilution.
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ARG44069 anti-PRMT7 antibody WB image
Western blot: Hela stained with ARG44069 anti-PRMT7 antibody at 0.5 μg/mL dilution.
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ARG44069 anti-PRMT7 antibody FACS image
Flow Cytometry: HepG2 stained with ARG44069 anti-PRMT7 antibody at 1 μg/1x10^6 cells dilution.
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ARG44069 anti-PRMT7 antibody IHC-P image
Immunohistochemistry: Rat testis stained with ARG44069 anti-PRMT7 antibody at 2 μg/mL dilution.
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ARG44069 anti-PRMT7 antibody IHC-P image
Immunohistochemistry: Mouse testis stained with ARG44069 anti-PRMT7 antibody at 2 μg/mL dilution.
