ARG59652

anti-PRMT2 antibody

anti-PRMT2 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes PRMT2
Tested Reactivity Hu, Ms
Predict Reactivity Cow, Rat, Dog, Gpig, Hrs, Pig, Rb
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PRMT2
Antigen Species Human
Immunogen Synthetic peptide around the N-terminal region of Human PRMT2. (within the following region: ESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILIL)
Conjugation Un-conjugated
Alternate Names EC 2.1.1.125; Histone-arginine N-methyltransferase PRMT2; HRMT1L1; Protein arginine N-methyltransferase 2; EC 2.1.1.-

Application Instructions

Predict Reactivity Note Predicted Homology Based On Immunogen Sequence: Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%
Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS, 0.09% (w/v) Sodium azide and 2% Sucrose.
Preservative 0.09% (w/v) Sodium azide
Stabilizer 2% Sucrose
Concentration Batch dependent: 0.5 - 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3275 Human PRMT2

Swiss-port # P55345 Human Protein arginine N-methyltransferase 2

Gene Symbol PRMT2
Gene Full Name protein arginine methyltransferase 2
Function Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
Cellular Localization Isoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus. Isoform PRMT2Alpha: Nucleus. Note=Excluded from nucleolus. Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus. Isoform PRMT2Gamma: Nucleus. Note=Excluded from nucleolus. Isoform PRMT2L2: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. [UniProt]
Calculated MW 49 kDa

Images (2) Click the Picture to Zoom In

  • ARG59652 anti-PRMT2 antibody WB image

    Western blot: Jurkat cell lysate stained with ARG59652 anti-PRMT2 antibody at 0.625 µg/ml dilution.

  • ARG59652 anti-PRMT2 antibody WB image

    Western blot: Human LCL and Mouse brain lysates stained with ARG59652 anti-PRMT2 antibody at 1:1000 dilution.