ARG56526
anti-PNPLA2 / ATGL antibody
anti-PNPLA2 / ATGL antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PNPLA2 / ATGL |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PNPLA2 / ATGL |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around aa. 382-400 of Human Adipose Triglyceride Lipase (ATGL). (KRKLGRHLPSRLPEQVELR) |
| Conjugation | Un-conjugated |
| Alternate Names | Transport-secretion protein 2; Pigment epithelium-derived factor; TTS2.2; FP17548; 1110001C14Rik; TTS2; PEDF-R; IPLA2-zeta; ATGL; Calcium-independent phospholipase A2; TTS-2.2; Patatin-like phospholipase domain-containing protein 2; iPLA2zeta; Desnutrin; Adipose triglyceride lipase; EC 3.1.1.3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | TBS (pH 7.4) |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PNPLA2 |
| Gene Full Name | patatin-like phospholipase domain containing 2 |
| Background | This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010] |
| Function | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. [UniProt] |
| Calculated MW | 55 kDa |
| PTM | Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation. |
Images (1) Click the Picture to Zoom In
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ARG56526 anti-PNPLA2 / ATGL antibody WB image
Western blot: 1) 50 µg of Human liver microsome, 2) 50 µg of HepG2 cell lysate, 3) 50 µg of Rat brown fat homogenate, and 4) 50 µg of Mouse liver 100,000 x g pellet stained with ARG56526 anti-PNPLA2 / ATGL antibody.
