ARG44386
anti-PLA2G3 antibody
anti-PLA2G3 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PLA2G3 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PLA2G3 |
| Antigen Species | Human |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PLA2G3 |
| Conjugation | Un-conjugated |
| Alternate Names | LA2G3; Phospholipase A2 Group III; GIII-SPLA2; Phosphatidylcholine 2-Acylhydrolase 3; Group 3 Secretory Phospholipase A2; SPLA2-III; Phosphatidylcholine 2-Acylhydrolase GIII; Group III Secretory Phospholipase A2; Group III Secreted Phospholipase A2; Phospholipase A2, Group III; GIII SPLA2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.01% Thimerosal and 50% Glycerol. |
| Preservative | 0.01% Thimerosal |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NZ20 Human Group 3 secretory phospholipase A2 |
|---|---|
| Gene Symbol | PLA2G3 |
| Gene Full Name | Phospholipase A2 Group III |
| Background | This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. |
| Function | Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity. |
| Cellular Localization | Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane, Secreted |
| Calculated MW | 57 kDa |
| PTM | Disulfide bond, Glycoprotein |
Images (2) Click the Picture to Zoom In
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ARG44386 anti-PLA2G3 antibody WB image
Western blot: 293T stained with ARG44386 anti-PLA2G3 antibody at 1:1000 dilution.
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ARG44386 anti-PLA2G3 antibody WB image
Western blot: Mouse liver stained with ARG44386 anti-PLA2G3 antibody at 1:1000 dilution.
