ARG56405
anti-PITRM1 antibody
anti-PITRM1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PITRM1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PITRM1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human PITRM1 |
| Conjugation | Un-conjugated |
| Alternate Names | Presequence protease, mitochondrial; hPreP; EC 3.4.24.-; Metalloprotease 1; MP1; hMP1; Pitrilysin metalloproteinase 1; PreP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | U87 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q5JRX3 Human Presequence protease, mitochondrial Swiss-port # Q8K411 Mouse Presequence protease, mitochondrial |
|---|---|
| Gene Symbol | PITRM1 |
| Gene Full Name | pitrilysin metallopeptidase 1 |
| Function | ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. [UniProt] |
| Calculated MW | 117 kDa |
| PTM | The disulfide bond may lock the enzyme in a closed conformation under oxidized conditions, suggesting that it may participate in redox regulation of the enzyme. |
Images (1) Click the Picture to Zoom In
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ARG56405 anti-PITRM1 antibody WB image
Western blot: U87 cell lysate stained with ARG56405 anti-PITRM1 antibody.
