ARG10793
anti-PDE1C antibody
anti-PDE1C antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PDE1C |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PDE1C |
| Antigen Species | Human |
| Immunogen | Synthetic peptide from Human PDE1C. |
| Conjugation | Un-conjugated |
| Alternate Names | Hcam3; cam-PDE 1C; EC 3.1.4.17; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; hCam-3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PDE1C |
| Gene Full Name | phosphodiesterase 1C, calmodulin-dependent 70kDa |
| Background | Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009] |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. [UniProt] |
| Calculated MW | PDE1C1: 76 kDa PDE1C2: 70 kDa |
Images (3) Click the Picture to Zoom In
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ARG10793 anti-PDE1C antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human ovarian medulla tissue stained with ARG10793 anti-PDE1C antibody at 1:1500 dilution.
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ARG10793 anti-PDE1C antibody WB image
Western blot: Recombinant PDE1C2 and PDE1C1 protein stained with ARG10793 anti-PDE1C antibody at 1:500 dilution.
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ARG10793 anti-PDE1C antibody WB image
Western blot: 50 µg of Rat brain on SDS-PAGE stained with ARG10793 anti-PDE1C antibody at 1:250 dilution.
