ARG10817
anti-PDE11A phospho (Ser117 / Ser124) antibody
anti-PDE11A phospho (Ser117 / Ser124) antibody for ELISA,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PDE11A phospho (Ser117 / Ser124) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PDE11A |
| Antigen Species | Human |
| Immunogen | Synthetic peptide taken within aa. 100-150 from PDE11A protein. Phosphorylated at Ser117 and Ser124. |
| Conjugation | Un-conjugated |
| Alternate Names | EC 3.1.4.35; PPNAD2; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; EC 3.1.4.53 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | ~ 105 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PDE11A |
| Gene Full Name | phosphodiesterase 11A |
| Background | The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. [UniProt] |
| Calculated MW | 105 kDa |
Images (2) Click the Picture to Zoom In
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ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody WB image
Western blot: GFP-PDE11A variants stained with ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody.
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ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody WB image
Western blot: 1) Rat testis, and 2) Rat liver (Negative control) stained with ARG10817 anti-PDE11A phospho (Ser117 / Ser124) antibody at 1:250 dilution, 1 hour incubation at RT.
