ARG44806
anti-P50 Dynamitin antibody
anti-P50 Dynamitin antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes P50 Dynamitin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | P50 Dynamitin |
| Antigen Species | Human |
| Epitope | GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK RVGTKGLDFS DRIGKTKRTG YESGEYEMLG EGLGVKETPQ QKYQRLLHEV QELTTEVEKI KTTVKESATE EKLTPVLLAK QLAALKQQLV ASHLEKLLGP DAAINLTDPD GALAKRLLLQ LEATKNSKGG SGGKTTGTPP |
| Conjugation | Un-conjugated |
| Alternate Names | DCTN2; Dynactin Subunit 2; DCTN-50; RBP50; 50 KDa Dynein-Associated Polypeptide; Dynactin Complex 50 KDa Subunit; Dynactin 2 (P50); P50 Dynamitin; DCTN50; Epididymis Secretory Sperm Binding Protein; Epididymis Secretory Protein Li 77; DYNAMITIN; HEL-S-77 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | DCTN2 |
| Gene Full Name | Dynactin Subunit 2 |
| Background | This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| Function | Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. [Uniprot] |
| Cellular Localization | Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule. [Uniprot] |
| PTM | Acetylation, Phosphoprotein. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG44806 anti-P50 Dynamitin antibody IHC-P image
Immunohistochemistry: Human endometrium stained with ARG44806 anti-P50 Dynamitin antibody at 5 µg/mL dilution.
