ARG54602
anti-P Cadherin antibody [NCC-CAD-299]
anti-P Cadherin antibody [NCC-CAD-299] for Immunohistochemistry,Western blot and Human
Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [NCC-CAD-299] recognizes P Cadherin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC, WB |
| Specificity | This antibody specifically reacts withhuman P-Cadherin, and inhibits PCadherindependent cell-cell contact |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NCC-CAD-299 |
| Isotype | IgG1 |
| Target Name | P Cadherin |
| Antigen Species | Human |
| Immunogen | Human epidermal carcinomacell line A431. |
| Conjugation | Un-conjugated |
| Alternate Names | PCAD; Cadherin-3; P-cadherin; HJMD; Placental cadherin; CDHP |
Application Instructions
| Application Note | Western blot: 5 - 10 ug/ml, nonreducing and non - heating conditions. Immunohistochemistry: 5 - 10 ug/ml, * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Buffer | 10 mM PBS (pH 7.4) and 1% BSA |
| Stabilizer | 1% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CDH3 |
| Gene Full Name | cadherin 3, type 1, P-cadherin (placental) |
| Background | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008] |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. [UniProt] |
| Research Area | Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 91 kDa |
Clone References
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells.
Inhib / Human
