ARG10528
anti-Osteocalcin antibody [2H9]
anti-Osteocalcin antibody [2H9] for ELISA and Human
Developmental Biology antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [2H9] recognizes Osteocalcin |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Bov, Rat, Pig |
| Species Does Not React With | Ms |
| Tested Application | ELISA |
| Specificity | This antibody cross-reacts with bovine, rat and pig Osteocalcin and is not cross-reacting with mouse Osteocalcin. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 2H9 |
| Isotype | IgG2a |
| Target Name | Osteocalcin |
| Antigen Species | Human |
| Immunogen | Recombinant Human Osteocalcin with glutathione S-transferase |
| Conjugation | Un-conjugated |
| Alternate Names | OCN; Gamma-carboxyglutamic acid-containing protein; Osteocalcin; OC; Bone Gla protein; BGP |
Application Instructions
| Application Note | Recommended pairs for sandwich immunoassay (capture-detection): ARG10528 - ARG10529 (detects the large NH2- terminal fragment and intact hOC) |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS (pH 7.4) and 0.09 % Sodium azide |
| Preservative | 0.09 % Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BGLAP |
| Gene Full Name | bone gamma-carboxyglutamate (gla) protein |
| Background | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015] |
| Function | Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. [UniProt] |
| Highlight | Related Antibody Duos and Panels: ARG30290 Osteocalcin ELISA Antibody Duo Related products: Osteocalcin antibodies; Osteocalcin ELISA Kits; Osteocalcin Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| Research Area | Developmental Biology antibody; Signaling Transduction antibody |
| Calculated MW | 11 kDa |
| PTM | Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. |
