Overview

Product Description	Rabbit Polyclonal antibody recognizes NrCAM
Tested Reactivity	Hu
Tested Application	IP, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	NrCAM
Antigen Species	Human
Immunogen	Synthetic peptide of Human NrCAM.
Conjugation	Un-conjugated
Alternate Names	Nr-CAM; Ng-CAM-related; hBravo; Neuronal surface protein Bravo; Neuronal cell adhesion molecule; NgCAM-related cell adhesion molecule

Application Instructions

Application Suggestion	Tested Application Dilution IP 1:20 WB 1:1000 - 1:5000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	Human forebrain
Observed Size	~ 145 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 4897 Human NRCAM Swiss-port # Q92823 Human Neuronal cell adhesion molecule
Gene Symbol	NRCAM
Gene Full Name	neuronal cell adhesion molecule
Background	Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Function	Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity). [UniProt]
Cellular Localization	Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted. Note=Detected at nodes of Ranvier. [UniProt]
Calculated MW	144 kDa

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