ARG64239
anti-Neuregulin 3 antibody
anti-Neuregulin 3 antibody for Western blot and Human,Mouse,Rat
Cancer antibody; Neuroscience antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes Neuregulin 3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Predict Reactivity | Dog |
| Tested Application | WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Neuregulin 3 |
| Antigen Species | Human |
| Immunogen | C-RNEIQRDSALTK |
| Conjugation | Un-conjugated |
| Alternate Names | Pro-NRG3; pro-NRG3; Pro-neuregulin-3, membrane-bound isoform; HRG3; NRG-3 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O35181 Mouse Pro-neuregulin-3, membrane-bound isoform Swiss-port # P56975 Human Pro-neuregulin-3, membrane-bound isoform |
|---|---|
| Background | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
| Research Area | Cancer antibody; Neuroscience antibody |
| Calculated MW | 78 kDa |
| PTM | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated. |
Images (1) Click the Picture to Zoom In
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ARG64239 anti-Neuregulin 3 antibody WB image
Western Blot: Human Brain (Cerebellum) lysate (35 µg protein in RIPA buffer) stained with ARG64239 anti-Neuregulin 3 antibody at 0.3 µg/ml dilution.
