ARG44477
anti-NUMBL antibody
anti-NUMBL antibody for Western blot,Flow cytometry and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NUMBL |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | NUMBL |
| Antigen Species | Human |
| Immunogen | Human NUMBL recombinant protein |
| Conjugation | Un-conjugated |
| Alternate Names | NUMBL; NUMB Like Endocytic Adaptor Protein; NUMBLIKE; NUMB-R; TNRC23; CTG3a; CAG3A; NUMBR; Numb-Related Protein; Numb-Like Protein; Numb (Drosophila) Homolog-Like; Numb Homolog-Like; Numb-R; NBL |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NUMBL |
| Gene Full Name | NUMB Like Endocytic Adaptor Protein |
| Background | Involved in cytokine-mediated signaling pathway and protein metabolic process. Predicted to be active in cytoplasm. |
| Function | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
| Cellular Localization | Cytoplasm |
| Calculated MW | 65 kDa |
| PTM | Phosphoprotein |
Images (4) Click the Picture to Zoom In
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ARG44477 anti-NUMBL antibody WB image
Western blot: HeLa and U-87 MG stained with ARG44477 anti-NUMBL antibody at 0.5 μg/mL dilution.
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ARG44477 anti-NUMBL antibody FACS image
Flow Cytometry: U87 stained with ARG44477 anti-NUMBL antibody at 1 μg/10^6 cells dilution.
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ARG44477 anti-NUMBL antibody WB image
Western blot: Rat brain stained with ARG44477 anti-NUMBL antibody at 0.5 μg/mL dilution.
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ARG44477 anti-NUMBL antibody WB image
Western blot: Mouse brain and Mouse lung stained with ARG44477 anti-NUMBL antibody at 0.5 μg/mL dilution.
