ARG45657
anti-NSMCE4A antibody
anti-NSMCE4A antibody for Flow cytometry,ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NSMCE4A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NSMCE4A |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human NSMCE4A. |
| Conjugation | Un-conjugated |
| Alternate Names | NSMCE4A; NSE4 Homolog A, SMC5-SMC6 Complex Component; C10orf86; NSE4A; Non-Structural Maintenance Of Chromosomes Element 4 Homolog A; NSE4 Homolog, SMC5-SMC6 Complex Component A; Non-SMC Element 4 Homolog A; BA500G22.3; FLJ20003; NS4EA; Non-SMC Element 4 Homolog A (S. Cerevisiae); Chromosome 10 Open Reading Frame 86 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 50 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NXX6 Human Non-structural maintenance of chromosomes element 4 homolog A |
|---|---|
| Gene Symbol | NSMCE4A |
| Gene Full Name | NSE4 Homolog A, SMC5-SMC6 Complex Component |
| Background | Involved in DNA damage response. Located in nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Feb 2025] |
| Function | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. [UniProt] |
| Cellular Localization | Chromosome; Nucleus; Telomere. [UniProt] |
| Calculated MW | 44 kDa |
| PTM | Phosphoprotein. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45657 anti-NSMCE4A antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45657 anti-NSMCE4A antibody at 5 μg/ml dilution.
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ARG45657 anti-NSMCE4A antibody WB image
Western blot: 293T and HepG2 stained with ARG45657 anti-NSMCE4A antibody at 0.5 μg/ml dilution.
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ARG45657 anti-NSMCE4A antibody FACS image
Flow Cytometry: JK stained with ARG45657 anti-NSMCE4A antibody at 1 µg/10^6 cells dilution.
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ARG45657 anti-NSMCE4A antibody WB image
Western blot: RH35 stained with ARG45657 anti-NSMCE4A antibody at 0.5 μg/ml dilution.
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ARG45657 anti-NSMCE4A antibody WB image
Western blot: Mouse ovary stained with ARG45657 anti-NSMCE4A antibody at 0.5 μg/ml dilution.
