ARG43839
anti-NRAMP1 / SLC11A1 Antibody
anti-NRAMP1 / SLC11A1 Antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal Antibody recognizes NRAMP1 / SLC11A1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Target Name | SLC11A1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide between 250-276 of human NRAMP1/SLC11A1 |
| Conjugation | Un-conjugated |
| Protein Full Name | Natural resistance-associated macrophage protein 1 |
| Alternate Names | SLC11A1; Solute Carrier Family 11 Member 1; Natural Resistance-Associated Macrophage Protein 1; NRAMP1; NRAMP; LSH; Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporter), Member 1; Leishmaniasis Resistance; NRAMP 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification. |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P49279 Human Natural resistance-associated macrophage protein 1 |
|---|---|
| Gene Symbol | 6556 |
| Gene Full Name | Solute Carrier Family 11 Member 1 |
| Background | This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. |
| Function | Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. |
| Cellular Localization | Membrane |
| Calculated MW | 60 |
| PTM | Glycoprotein |
Images (1) Click the Picture to Zoom In
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ARG43839 anti-NRAMP1/SLC11A1 Antibody WB image
Western blot: Human Liver stained with ARG43839 anti-NRAMP1/SLC11A1 Antibody antibody at 1:1000.
