ARG22070

anti-NKG2A + C + E antibody [20d5] (PE)

anti-NKG2A + C + E antibody [20d5] (PE) for Blocking,Flow cytometry and Mouse

Overview

Product Description PE-conjugated Rat Monoclonal antibody [20d5] recognizes NKG2A + C + E
Tested Reactivity Ms
Tested Application BL, FACS
Specificity Mouse NKG2-A + C + E
Host Rat
Clonality Monoclonal
Clone 20d5
Isotype IgG2a, kappa
Target Name NKG2A + C + E
Antigen Species Mouse
Immunogen CHO cells transfected with B6 allele of NKG2A gene
Conjugation PE
Alternate Names NK cell receptor A; CD159 antigen-like family member A; NKG2-A/NKG2-B type II integral membrane protein; CD159A; CD antigen CD159a; NKG2; NKG2A; NKG2-A/B-activating NK receptor

Application Instructions

Application Suggestion
Tested Application Dilution
BLAssay-dependent
FACS< 0.2 µg/10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer PBS, 0.1% Sodium azide and Sucrose.
Preservative 0.1% Sodium azide
Stabilizer Sucrose
Concentration 0.1 mg/ml
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol KLRC1
Gene Full Name killer cell lectin-like receptor subfamily C, member 1
Background Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
Function Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. [UniProt]
Calculated MW 26 kDa

Images (1) Click the Picture to Zoom In

  • ARG22070 anti-NKG2A + C + E antibody [20d5] (PE) FACS image

    Flow Cytometry: C57BL/6 Mouse splenocytes stained with ARG22070 anti-NKG2A + C + E antibody [20d5] (PE) and ARG22072 anti-NK1.1 / CD161bc antibody [PK136] (FITC).