ARG22069
anti-NKG2A + C + E antibody [20d5] (Biotin)
anti-NKG2A + C + E antibody [20d5] (Biotin) for Blocking,Flow cytometry and Mouse
Overview
| Product Description | Biotin-conjugated Rat Monoclonal antibody [20d5] recognizes NKG2A + C + E |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | BL, FACS |
| Specificity | Mouse NKG2-A + C + E |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 20d5 |
| Isotype | IgG2a, kappa |
| Target Name | NKG2A + C + E |
| Antigen Species | Mouse |
| Immunogen | CHO cells transfected with B6 allele of NKG2A gene |
| Conjugation | Biotin |
| Alternate Names | NK cell receptor A; CD159 antigen-like family member A; NKG2-A/NKG2-B type II integral membrane protein; CD159A; CD antigen CD159a; NKG2; NKG2A; NKG2-A/B-activating NK receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Concentration | 0.5 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | KLRC1 |
|---|---|
| Gene Full Name | killer cell lectin-like receptor subfamily C, member 1 |
| Background | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015] |
| Function | Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. [UniProt] |
| Calculated MW | 26 kDa |
Images (1) Click the Picture to Zoom In
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ARG22069 anti-NKG2A + C + E antibody [20d5] (Biotin) FACS image
Flow Cytometry: C57BL/6 Mouse splenocytes stained with ARG22069 anti-NKG2A + C + E antibody [20d5] (Biotin) and ARG65527 anti-CD161bc / NK1.1 antibody [PK136] (PE) followed by Streptavidin (FITC).
