ARG43906
anti-NFE2 antibody
anti-NFE2 antibody for ELISA,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NFE2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | NFE2 |
| Antigen Species | Human |
| Immunogen | Human NFE2 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | Transcription factor NF-E2 45 kDa subunit |
| Alternate Names | NFE2; Nuclear Factor, Erythroid 2; NF-E2; Nuclear Factor, Erythroid-Derived 2 45 KDa Subunit; Transcription Factor NF-E2 45 KDa Subunit; Leucine Zipper Protein NF-E2; P45 NF-E2; P45 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # Q16621 Human Transcription factor NF-E2 45 kDa subunit |
|---|---|
| Gene Symbol | NFE2 |
| Gene Full Name | Nuclear Factor, Erythroid 2 |
| Background | Enables several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Contributes to cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Part of protein-DNA complex. |
| Function | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 42 kDa |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation |
Images (1) Click the Picture to Zoom In
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ARG43906 anti-NFE2 antibody WB image
Western blot: K562 and HepG2 stained with ARG43906 anti-NFE2 antibody at 0.5 μg/mL dilution.
