ARG44879
anti-NFAT5 antibody
anti-NFAT5 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes NFAT5 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | NFAT5 |
| Antigen Species | Human |
| Epitope | GQYPVKSEGK ELKIVVQPET QHRARYLTEG SRGSVKDRTQ QGFPTVKLEG HNEPVVLQVF VGNDSGRVKP HGFYQACRVT GRNTTPCKEV DIEGTTVIEV GLDPSNNMTL AVDCVGILKL RNADVEARIG IAGSKKKSTR ARLVFRVNIM RKDGSTLTLQ TPSSPILCTQ PAGVPEILKK SLHSCSVKGE EEVFLIGKNF LKGTKVIFQE NVSDENSWKS EAEIDMELFH QNHLIVKVPP YHDQHITLPV SVGIYVVTNA GRSHDVQPFT |
| Conjugation | Un-conjugated |
| Alternate Names | NFAT5; Nuclear Factor Of Activated T Cells 5; TONEBP; NF-AT5; Nuclear Factor Of Activated T-Cells 5; KIAA0827; NFATL1; OREBP; NFATZ; Nuclear Factor Of Activated T-Cells 5, Tonicity-Responsive; Tonicity-Responsive Enhancer-Binding Protein; T-Cell Transcription Factor NFAT5; TonE-Binding Protein; Tonicity-Responsive Enhancer Binding Protein; Osmotic Response Element-Binding Protein; Glutamine Rich Protein H65; NFAT-Like Protein 1; EC 3.6.3.14; EC 3.6.1; TonEBP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O94916 Human Nuclear factor of activated T-cells 5 |
|---|---|
| Gene Symbol | NFAT5 |
| Gene Full Name | Nuclear Factor Of Activated T Cells 5 |
| Background | The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. [Uniprot] |
| Cellular Localization | Chromosome, Cytoplasm, Nucleus. [Uniprot] |
| PTM | Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG44879 anti-NFAT5 antibody IHC-P image
Immunohistochemistry: Human spleen stained with ARG44879 anti-NFAT5 antibody at 5 µg/mL dilution.
