ARG44024
anti-N-Ras antibody
anti-N-Ras antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes N-RAS |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Pig |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | N-RAS |
| Antigen Species | Human |
| Immunogen | Human N-RAS recombinantprotein |
| Conjugation | Un-conjugated |
| Protein Full Name | GTPase Nras |
| Alternate Names | NRAS; NRAS Proto-Oncogene, GTPase; N-Ras; Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog; Neuroblastoma RAS Viral Oncogene Homolog; Transforming Protein N-Ras; GTPase NRas; V-Ras Neuroblastoma RAS Viral Oncogene Homolog; Proto-Oncogene GTPase; N-Ras Protein Part 4; EC 3.6.5.2; ALPS4; NRAS1; HRAS1; CMNS; KRAS; NCMS; NS6 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS containing 0.02% sodium azide |
| Preservative | 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NRAS |
| Gene Full Name | NRAS Proto-Oncogene, GTPase |
| Background | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. |
| Function | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
| Cellular Localization | Cell membrane, Golgi apparatus, Membrane |
| Calculated MW | 21 kDa |
| PTM | Acetylation, Glycoprotein, Isopeptide bond, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation, Ubl conjugation |
Images (1) Click the Picture to Zoom In
-
ARG44024 anti-N-Ras antibody WB image
Western blot: A431 stained with ARG44024 anti-N-Ras antibody at 2 μg/mL dilution.
