ARG45543
anti-Mucin 5AC antibody [45M1]
anti-Mucin 5AC antibody [45M1] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat,Rabbit
Overview
| Product Description | Mouse Monoclonal antibody [45M1] recognizes MUC5B |
|---|---|
| Tested Reactivity | Hu, Rat, Rb |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 45M1 |
| Isotype | IgG1 |
| Target Name | Mucin 5AC |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | leB; Major airway glycoprotein; Lewis B blood group antigen; Tracheobronchial mucin; mucin; Mucin-5AC; LeB; MUC5; TBM; Gastric mucin; MUC-5AC; Mucin-5 subtype AC, tracheobronchial |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Ascites |
| Buffer | Mouse ascites fluid, 1.2% Sodium acetate, 0.01 mg Sodium azide and 2 mg BSA. |
| Preservative | 0.01 mg Sodium azide |
| Stabilizer | 2 mg BSA |
| Concentration | 0.1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MUC5AC |
| Gene Full Name | mucin 5AC, oligomeric mucus/gel-forming |
| Background | Predicted to enable extracellular matrix constituent, lubricant activity. Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within maintenance of lens transparency. Located in extracellular space and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple). [provided by Alliance of Genome Resources, Feb 2025] |
| Function | Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 586 kDa |
| PTM | C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG45543 anti-Mucin 5AC antibody [45M1] IHC-P image
Immunohistochemistry: Human colon cancer stained with ARG45543 anti-Mucin 5AC antibody [45M1] at 2 μg/ml dilution.
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ARG45543 anti-Mucin 5AC antibody [45M1] IHC-P image
Immunohistochemistry: Rat colon stained with ARG45543 anti-Mucin 5AC antibody [45M1] at 2 μg/ml dilution.
