ARG67107
anti-MUTYH antibody
anti-MUTYH antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MUTYH |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MUTYH |
| Antigen Species | Human |
| Immunogen | Human MUTYH Synthesized peptide |
| Conjugation | Un-conjugated |
| Alternate Names | MUTYH; MutY DNA Glycosylase MYH; Adenine DNA Glycosylase; MutY Homolog; A/G-Specific Adenine DNA Glycosylase; MutY Homolog (E. Coli); MutY-Like Protein; EC 3.2.2.31; EC 3.2.2; HMYH |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MUTYH |
| Gene Full Name | MutY DNA Glycosylase |
| Background | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. |
| Cellular Localization | Mitochondrion, Nucleus |
| Calculated MW | 60 kDa |
Images (3) Click the Picture to Zoom In
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ARG67107 anti-MUTYH antibody IHC-P image
Immunohistochemistry: Human Small intestinal stained with ARG67107 anti-MUTYH antibody at 1:200 dilution.
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ARG67107 anti-MUTYH antibody ICC/IF image
Immunofluorescence: A549 stained with ARG67107 anti-MUTYH antibody
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ARG67107 anti-MUTYH antibody WB image
Western blot: HeLa and HepG2 stained with ARG67107 anti-MUTYH antibody at 1:1000 dilution.
