ARG44427
anti-MUTYH antibody
anti-MUTYH antibody for Flow cytometry,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MUTYH |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MUTYH |
| Antigen Species | Human |
| Immunogen | Human MUTYH recombinant protein (aa. sequence: M1-R559). |
| Conjugation | Un-conjugated |
| Alternate Names | MUTYH; MutY DNA Glycosylase; MYH; Adenine DNA Glycosylase; MutY Homolog; A/G-Specific Adenine DNA Glycosylase; MutY Homolog (E. Coli); MutY-Like Protein |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # Q8R5G2 Rat A/G-specific adenine DNA glycosylase Swiss-port # Q9UIF7 Human A/G-specific adenine DNA glycosylase |
|---|---|
| Gene Symbol | MUTYH |
| Gene Full Name | MutY DNA Glycosylase |
| Background | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. |
| Cellular Localization | Mitochondrion, Nucleus |
| Calculated MW | 60 kDa |
Images (3) Click the Picture to Zoom In
-
ARG44427 anti-MUTYH antibody WB image
Western blot: HeLa and K562 stained with ARG44427 anti-MUTYH antibody at 0.5 μg/mL dilution.
-
ARG44427 anti-MUTYH antibody FACS image
Flow Cytometry: HeLa stained with ARG44427 anti-MUTYH antibody at 1 μg/10^6 cells dilution.
-
ARG44427 anti-MUTYH antibody WB image
Western blot: C6 stained with ARG44427 anti-MUTYH antibody at 0.5 μg/mL dilution.
