ARG44874
anti-MTHFD2 antibody
anti-MTHFD2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot,Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes MTHFD2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | MTHFD2 |
| Antigen Species | Human |
| A.A. Sequence | TIMKPASISE EELLNLINKL NNDDNVDGLL VQLPLPEHID ERRICNAVSP DKDVDGFHVI NVGRMCLDQY SMLPATPWGV WEIIKRTGIP TLGKNVVVAG RSKNVGMPIA MLLHTDGAHE RPGGDATVTI SHRYTPKEQL KKHTILADIV ISAAGIPNLI TADMIKEGAA VIDVGINRVH DPVTAKPKLV GDVDFEGVRQ |
| Conjugation | Un-conjugated |
| Alternate Names | MTHFD2; Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase; Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial; NMDMC; NAD-Dependent Methylene Tetrahydrofolate Dehydrogenase Cyclohydrolase |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # P13995 Human Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitoc |
|---|---|
| Gene Symbol | MTHFD2 |
| Gene Full Name | Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase |
| Background | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
| Function | Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. [UniProt] |
| Cellular Localization | Mitochondrion. [UniProt] |
| PTM | Acetylation, Isopeptide bond, Ubl conjugation. [UniProt] |
